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CS-W001157 4
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Methyl 2-(2-bromothiazol-4-yl)acetate

  • CAS No. 1261589-82-5

  • Cat. No. CS-0179630
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 2-(2-bromothiazol-4-yl)acetate|CS-0179630

Structure of 1261589-82-5

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General Information

  • CAS No. 1261589-82-5
  • Cat. No. CS-0179630
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrNO₂S
  • Molecular Weight 236.09
  • Synonym(s) methyl 2-(2-bromo-1,3-thiazol-4-yl)acetate
  • SMILES O=C(OC)CC1=CSC(Br)=N1

Description

Methyl 2-(2-bromothiazol-4-yl)acetate features a brominated thiazole ring linked to a methyl ester-functionalized acetic acid moiety. This electrophilic scaffold integrates readily into cross-coupling reactions and serves as a key intermediate in synthesizing bioactive heterocycles. The bromine atom enables palladium-catalyzed transformations, while the ester group offers versatility in derivatization under standard conditions.

Application

Methyl 2-(2-bromothiazol-4-yl)acetate serves as a versatile building block for thiazole-based scaffolds, enabling palladium-catalyzed cross-coupling reactions with broad functional group tolerance. The bromine atom facilitates efficient C–C bond formation, while the ester group offers further derivatization potential. Its bench-stable nature and compatibility with standard synthetic protocols make it a practical choice for constructing medicinally relevant heterocycles in R&D workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.6211
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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