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Structure of 1261629-31-5
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2-Chloro-4-(difluoromethyl)pyrimidine integrates a difluoromethyl group into a pyrimidine scaffold, delivering enhanced metabolic stability and electron-withdrawing character. This configuration supports efficient coupling reactions and facilitates incorporation into bioactive molecules requiring fluorinated alkyl motifs.
2-Chloro-4-(difluoromethyl)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient incorporation of the difluoromethyl group—a bioisostere of halogens and alkyls—into target molecules. Its chloropyrimidine moiety facilitates nucleophilic substitution and cross-coupling reactions, while the difluoromethyl group enhances metabolic stability and modulates lipophilicity. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it a reliable reagent for constructing pharmaceutically relevant heterocyclic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: