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CS-W001157 4
Total: USD 88.00

endo-BCN-O-PNB

  • CAS No. 1263166-91-1

  • Cat. No. CS-0084943
  • Purity≥96%
  • MDL No.MFCD19705415
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

endo-BCN-O-PNB|CS-0084943

Structure of 1263166-91-1

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Description

endo-BCN-O-PNB features a strained cyclooctyne core enabling rapid, bioorthogonal conjugation under physiological conditions. The pendant para-nitrobenzyl (PNB) group provides orthogonal cleavage capability, allowing site-specific release of payloads upon mild reduction. This dual-functionality supports efficient labeling and triggered deprotection in complex biological systems.

Application

endo-BCN-O-PNB serves as a robust, bench-stable cyclooctyne derivative for bioorthogonal labeling, enabling efficient strain-promoted azide-alkyne cycloaddition (SPAAC) under physiological conditions. The PNB (pentafluorophenyl) ester group facilitates direct conjugation with primary amines, offering orthogonal reactivity and clean purification via precipitation or dialysis. Its endo-configuration enhances ring strain and reaction kinetics, making it ideal for labeling biomolecules in complex environments.

General Information

  • CAS No. 1263166-91-1
  • Cat. No. CS-0084943
  • Purity ≥96%
  • MDL No. MFCD19705415
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₁₇NO₅
  • Molecular Weight 315.32
  • Synonym(s) None
  • SMILES O=C(OC1=CC=C([N+]([O-])=O)C=C1)OC[C@H]2[C@@]3([H])CCC#CCC[C@@]23[H]

Computational Chemistry Data

  • TPSA   78.67
  • LogP   3.5498
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   4

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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