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Structure of 1263166-91-1
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endo-BCN-O-PNB features a strained cyclooctyne core enabling rapid, bioorthogonal conjugation under physiological conditions. The pendant para-nitrobenzyl (PNB) group provides orthogonal cleavage capability, allowing site-specific release of payloads upon mild reduction. This dual-functionality supports efficient labeling and triggered deprotection in complex biological systems.
endo-BCN-O-PNB serves as a robust, bench-stable cyclooctyne derivative for bioorthogonal labeling, enabling efficient strain-promoted azide-alkyne cycloaddition (SPAAC) under physiological conditions. The PNB (pentafluorophenyl) ester group facilitates direct conjugation with primary amines, offering orthogonal reactivity and clean purification via precipitation or dialysis. Its endo-configuration enhances ring strain and reaction kinetics, making it ideal for labeling biomolecules in complex environments.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: