tert-Butyl 4-(6-chloropyridin-2-yl)piperidine-1-carboxylate

Name: tert-Butyl 4-(6-chloropyridin-2-yl)piperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 1266118-78-8
Cat. No. CS-0379052
Purity≥98%
MDL No.MFCD18206123

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl 4-(6-chloropyridin-2-yl)piperidine-1-carboxylate|CS-0379052

Structure of 1266118-78-8

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Description

tert-Butyl 4-(6-chloropyridin-2-yl)piperidine-1-carboxylate features a chloropyridine moiety linked to a piperidine scaffold, enabling direct incorporation into bioactive molecule synthesis. The tert-butyl ester group provides stability and facilitates straightforward deprotection under mild acidic conditions. This compound serves as a key intermediate in the development of kinase inhibitors and other pharmaceutical agents requiring a polar, electron-deficient heterocyclic core.

Application

tert-Butyl 4-(6-chloropyridin-2-yl)piperidine-1-carboxylate serves as a versatile building block for the synthesis of bioactive heterocycles, enabling direct functionalization at the pyridine ring and piperidine nitrogen. The tert-butyl carbamate group offers excellent bench stability and facile removal under mild acidic conditions. Its compatibility with palladium-catalyzed cross-coupling reactions facilitates efficient construction of complex scaffolds relevant to medicinal chemistry and process development.

General Information

CAS No. 1266118-78-8
Cat. No. CS-0379052
Purity ≥98%
MDL No. MFCD18206123
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₂₁ClN₂O₂
Molecular Weight 296.79
Synonym(s) None
SMILES O=C(N1CCC(C2=NC(Cl)=CC=C2)CC1)OC(C)(C)C

Computational Chemistry Data

TPSA 42.43
LogP 3.8495
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Drug Discovery Metabolic Disease GLP-1R

Key Words

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tert-Butyl 4-(6-chloropyridin-2-yl)piperidine-1-carboxylate

CAS No. 1266118-78-8

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