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CS-W001157 4
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4-Cyclopropylpyrrolidin-2-one

  • CAS No. 126822-39-7

  • Cat. No. CS-0006071
  • Molecule weight125.17
  • Purity≥98%
  • MDL No.MFCD18816888

*For research and further manufacturing use only, not for direct human use.

4-Cyclopropylpyrrolidin-2-one|CS-0006071

Structure of 126822-39-7

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General Information

  • CAS No. 126822-39-7
  • Cat. No. CS-0006071
  • Purity ≥98%
  • MDL No. MFCD18816888
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁NO
  • Molecular Weight 125.17
  • Synonym(s) 4-cyclopropyl-2-Pyrrolidinone
  • SMILES O=C1NCC(C2CC2)C1

Description

4-Cyclopropylpyrrolidin-2-one is a sterically constrained, bench-stable heterocycle featuring a cyclopropyl group at the 4-position and a ketone at C2. This configuration imparts enhanced metabolic stability and favorable lipophilicity, making it a valuable scaffold in medicinal chemistry for optimizing bioavailability and target engagement in CNS-directed therapeutics.

Application

4-Cyclopropylpyrrolidin-2-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard amide and alkylation transformations. Its cyclopropyl substituent imparts conformational rigidity and enhanced metabolic stability, while the pyrrolidinone core offers excellent functional group tolerance and bench stability, facilitating straightforward purification and integration into diverse synthetic sequences.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   0.5325
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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