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Structure of 126910-68-7
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Methyl 5-chloro-3-(chlorosulfonyl)thiophene-2-carboxylate features a thiophene core bearing strategically positioned chloro and chlorosulfonyl groups, enabling direct functionalization at the 5-position. The electrophilic chlorosulfonyl moiety facilitates sulfonation or displacement reactions under mild conditions. This bench-stable reagent integrates efficiently into heterocyclic synthesis workflows, offering precise control over substitution patterns in advanced pharmaceutical intermediates.
Methyl 5-chloro-3-(chlorosulfonyl)thiophene-2-carboxylate serves as a versatile building block for the synthesis of substituted thiophene derivatives. The chlorosulfonyl group enables direct nucleophilic substitution, while the methyl ester and adjacent chlorine facilitate further functionalization. This compound exhibits good bench stability and compatibility with standard coupling and cyclization protocols, making it valuable for constructing bioactive heterocyclic scaffolds in medicinal chemistry and agrochemical research.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P280-P301+P330+P331-P304+P340
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Lot numbers can be found on the outside label of a product: