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Structure of 128651-99-0
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6-Iodochroman-2-one is a bench-stable, electron-deficient heterocycle featuring a reactive iodine handle at the 6-position. This moiety enables direct coupling in palladium-catalyzed cross-coupling reactions, facilitating rapid access to complex biaryl architectures. The para-iodo substitution enhances reactivity while maintaining compatibility with diverse functional groups.
6-Iodochroman-2-one serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biaryl scaffolds. The iodine handle facilitates efficient C–C bond formation under standard Suzuki, Stille, or Negishi conditions, while the chroman-2-one core provides a rigid, pharmacophoric framework compatible with diverse functional group transformations. Bench-stable and readily purified by recrystallization, it supports scalable synthesis of complex heterocyclic intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: