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Structure of 1293285-04-7
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This fluorinated benzoic acid integrates a pyrimidin-2-yl moiety to enhance target engagement in kinase inhibition studies. The electron-deficient pyrimidine ring pairs with the ortho-fluoro substituent to modulate reactivity and solubility under standard conditions.
3-Fluoro-2-(pyrimidin-2-yl)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and API scaffolds. Its ortho-fluorinated aryl core enhances metabolic stability and modulates electronic properties, while the carboxylic acid functionality facilitates direct coupling reactions or derivatization. The pyrimidin-2-yl group provides a robust hydrogen-bonding acceptor site and contributes to favorable pharmacophore geometry. This compound exhibits excellent bench stability and is compatible with standard synthetic workflows, including amide formation, Suzuki-Miyaura coupling, and esterification.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H332
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
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Lot numbers can be found on the outside label of a product: