6-Chloro-3-methoxy-2-methylpyridine

Name: 6-Chloro-3-methoxy-2-methylpyridine
Brand: ChemScene
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CAS No. 129692-13-3
Cat. No. CS-0577217
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-3-methoxy-2-methylpyridine|CS-0577217

Structure of 129692-13-3

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Description

6-Chloro-3-methoxy-2-methylpyridine features a trifunctional pyridine core enabling selective coupling in medicinal chemistry. The chlorine at C6 facilitates palladium-catalyzed cross-coupling, while the methoxy group enhances solubility and modulates electronic properties. The methyl substituent at C2 provides steric and electronic control, improving reaction site selectivity. This compound serves as a key scaffold for kinase inhibitors and bioactive heterocycles under standard bench conditions.

Application

6-Chloro-3-methoxy-2-methylpyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through palladium-catalyzed cross-coupling reactions. Its chloro group exhibits high reactivity in Suzuki, Stille, and Buchwald–Hartwig transformations, while the methoxy and methyl substituents provide favorable electronic modulation and steric control. The compound demonstrates excellent bench stability and compatibility with standard purification methods, facilitating its use in multi-step synthesis of pharmaceutical intermediates and functionalized heterocycles.

General Information

CAS No. 129692-13-3
Cat. No. CS-0577217
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈ClNO
Molecular Weight 157.60
Synonym(s) None
SMILES CC1=C(C=CC(=N1)Cl)OC

Computational Chemistry Data

TPSA 22.12
LogP 2.05202
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-3-methoxy-2-methylpyridine

CAS No. 129692-13-3

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