2-Hydroxy-2-methylpropanamide

Name: 2-Hydroxy-2-methylpropanamide
Brand: ChemScene
Availability: InStock
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CAS No. 13027-88-8
Cat. No. CS-0154975
Purity≥97%
MDL No.MFCD08063365

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Hydroxy-2-methylpropanamide|CS-0154975

Structure of 13027-88-8

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Description

2-Hydroxy-2-methylpropanamide is a bench-stable, moisture-tolerant amide featuring a tertiary carbon bearing both hydroxyl and carbonyl functionalities. This structural motif enables direct incorporation into peptide mimetics and bioactive scaffolds, offering enhanced solubility and resistance to racemization during coupling reactions.

Application

2-Hydroxy-2-methylpropanamide serves as a stable, bench-ready synthon for the introduction of hydroxyl and amide functionalities in complex molecule synthesis. Its tertiary alcohol moiety enables direct functionalization or derivatization under mild conditions, while the amide group provides excellent stability and solubility in polar solvents. This compound facilitates efficient access to β-hydroxy amide motifs commonly found in bioactive scaffolds and peptide analogs.

General Information

CAS No. 13027-88-8
Cat. No. CS-0154975
Purity ≥97%
MDL No. MFCD08063365
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₉NO₂
Molecular Weight 103.12
Synonym(s) Propanamide, 2-hydroxy-2-methyl-
SMILES CC(C(N)=O)(O)C

Computational Chemistry Data

TPSA 63.32
LogP -0.7574
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

Quality Control

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Other Classifications

Building Blocks Functional Group Amide

Building Blocks Skeleton Fatty chain compounds

Key Words

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2-Hydroxy-2-methylpropanamide

CAS No. 13027-88-8

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