6-Bromo-7-chloroimidazo[1,2-a]pyridine

Name: 6-Bromo-7-chloroimidazo[1,2-a]pyridine
Brand: ChemScene
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CAS No. 1303890-45-0
Cat. No. CS-0102567
Molecule weight231.48
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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6-Bromo-7-chloroimidazo[1,2-a]pyridine|CS-0102567

Structure of 1303890-45-0

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General Information

CAS No. 1303890-45-0
Cat. No. CS-0102567
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄BrClN₂
Molecular Weight 231.48
Synonym(s) IMidazo[1,2-a]pyridine, 6-broMo-7-chloro-
SMILES ClC1=CC2=NC=CN2C=C1Br

Description

6-Bromo-7-chloroimidazo[1,2-a]pyridine features a fused heterocyclic core with complementary halogen substituents at the 6- and 7-positions, enabling selective cross-coupling reactions. The electron-deficient pyridine ring enhances reactivity in palladium-catalyzed transformations, while the sterically accessible framework supports efficient functionalization. This scaffold serves as a key building block for bioactive imidazopyridine derivatives in medicinal chemistry.

Application

6-Bromo-7-chloroimidazo[1,2-a]pyridine serves as a versatile building block in medicinal chemistry, enabling the construction of imidazo[1,2-a]pyridine scaffolds via palladium-catalyzed cross-coupling reactions. Its dual halogenation pattern supports sequential functionalization, offering orthogonal reactivity for C–C and C–heteroatom bond formation. The compound exhibits excellent bench stability and facilitates efficient purification, making it well-suited for scalable synthesis of bioactive heterocycles.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 17.3
LogP 2.7502
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Bromo-7-chloroimidazo[1,2-a]pyridine

CAS No. 1303890-45-0

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