Fmoc-α-Me-Tyr(tBu)-OH

Name: Fmoc-α-Me-Tyr(tBu)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 1309873-74-2
Cat. No. CS-0439220
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Fmoc-α-Me-Tyr(tBu)-OH is a protected tyrosine derivative featuring a fluorenylmethoxy carbonyl (Fmoc) group at the N-terminus and a tert-butyl ester on the phenolic hydroxyl. The α-methyl substitution enhances stability against racemization during peptide synthesis. This building block integrates efficiently into solid-phase sequences, offering robust handling and compatibility with standard coupling protocols.

Application

Fmoc-α-Me-Tyr(tBu)-OH serves as a key building block in peptide synthesis, enabling the incorporation of α-methyltyrosine with enhanced metabolic stability. The Fmoc group provides orthogonal protection for the amine, while the *tert*-butyl side chain ensures reliable deprotection under mild acidic conditions. This derivative exhibits excellent bench stability, facilitates efficient coupling reactions, and supports straightforward purification—making it ideal for constructing bioactive peptides and peptidomimetics.

General Information

CAS No. 1309873-74-2
Cat. No. CS-0439220
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₉H₃₁NO₅
Molecular Weight 473.56
Synonym(s) N-Fmoc-a-methyl-4-tert-butoxy-L-phenylalanine
SMILES C(OC(N[C@@](CC1=CC=C(OC(C)(C)C)C=C1)(C(O)=O)C)=O)C2C=3C(C=4C2=CC=CC4)=CC=CC3

Computational Chemistry Data

TPSA 84.86
LogP 5.7884
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 7

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Tyrosine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-α-Me-Tyr(tBu)-OH

CAS No. 1309873-74-2

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