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Structure of 1314400-72-0
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This trifluoromethyl-substituted pyrrole carboxylic acid features a strongly electron-deficient aromatic core, enhancing its utility in cross-coupling reactions and as a building block for bioactive heterocycles. The carboxylic acid group enables direct derivatization or metal complexation, while the trifluoromethyl moiety imparts metabolic stability and modulates lipophilicity.
5-(Trifluoromethyl)-1H-pyrrole-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid functionality facilitates direct amidation, esterification, or activation for peptide-like linkages. The compound exhibits good bench stability and compatibility with common synthetic protocols, making it suitable for iterative synthesis workflows in drug discovery programs.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: