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CS-W001157 4
Total: USD 88.00

(4-Bromopyridin-2-yl)methanol

  • CAS No. 131747-45-0

  • Cat. No. CS-W018599
  • Purity≥95%
  • MDL No.MFCD09800557
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

(4-Bromopyridin-2-yl)methanol|CS-W018599

Structure of 131747-45-0

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Description

(4-Bromopyridin-2-yl)methanol features a brominated pyridine ring linked to a primary alcohol group, enabling direct functionalization in cross-coupling and derivatization workflows. The pendant hydroxymethyl moiety supports facile oxidation to aldehyde or carboxylic acid derivatives, while the electron-deficient pyridine ring enhances reactivity in nucleophilic substitution reactions under standard conditions.

Application

(4-Bromopyridin-2-yl)methanol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine ring and side-chain hydroxymethyl group. It functions as a key intermediate in cross-coupling reactions, particularly Suzuki-Miyaura and Negishi transformations, due to its stable bromide handle and compatible aldehyde precursor. The molecule exhibits excellent bench stability and facilitates straightforward purification, making it ideal for modular synthesis of bioactive heterocycles and pharmaceutical scaffolds.

General Information

  • CAS No. 131747-45-0
  • Cat. No. CS-W018599
  • Purity ≥95%
  • MDL No. MFCD09800557
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrNO
  • Molecular Weight 188.02
  • Synonym(s) 4-Bromopyridine-2-methanol
  • SMILES BrC1=CC(=NC=C1)CO

Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.3364
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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