(2-Fluoropyridin-4-yl)methanol

Name: (2-Fluoropyridin-4-yl)methanol
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CAS No. 131747-60-9
Cat. No. CS-W006245
Purity≥98%
MDL No.MFCD06200782

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(2-Fluoropyridin-4-yl)methanol|CS-W006245

Structure of 131747-60-9

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Description

This fluorinated pyridine derivative features a reactive hydroxymethyl group at the 4-position, enabling straightforward functionalization. The electron-deficient pyridine ring enhances electrophilic reactivity, while the fluorine substituent imparts metabolic stability and modulates electronic properties. Ideal for medicinal chemistry applications requiring polar, rigid scaffolds with tunable solubility and bioavailability.

Application

(2-Fluoropyridin-4-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient incorporation of fluorinated pyridine motifs into target molecules. Its benzylic alcohol functionality facilitates straightforward derivatization—such as oxidation to the carboxylic acid or activation for coupling reactions—while maintaining compatibility with diverse reaction conditions. The molecule exhibits good bench stability and is readily purified by standard chromatographic methods, making it well-suited for use in multi-step synthesis and API development workflows.

General Information

CAS No. 131747-60-9
Cat. No. CS-W006245
Purity ≥98%
MDL No. MFCD06200782
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₆FNO
Molecular Weight 127.12
Synonym(s) 4-Pyridinemethanol,2-fluoro-
SMILES OCC1=CC(F)=NC=C1

Computational Chemistry Data

TPSA 33.12
LogP 0.713
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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(2-Fluoropyridin-4-yl)methanol

CAS No. 131747-60-9

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