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CS-W001157 4
Total: USD 88.00

(2-(Trifluoromethyl)pyridin-4-yl)methanol

  • CAS No. 131747-61-0

  • Cat. No. CS-W006203
  • Purity≥96%
  • MDL No.MFCD11100737

*For research and further manufacturing use only, not for direct human use.

(2-(Trifluoromethyl)pyridin-4-yl)methanol|CS-W006203

Structure of 131747-61-0

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General Information

  • CAS No. 131747-61-0
  • Cat. No. CS-W006203
  • Purity ≥96%
  • MDL No. MFCD11100737
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₃NO
  • Molecular Weight 177.12
  • Synonym(s) [2-(Trifluoromethyl)-4-pyridinyl]methanol
  • SMILES OCC1=CC(=NC=C1)C(F)(F)F

Description

This trifluoromethylpyridylmethanol features a strategically positioned trifluoromethyl group enhancing electron-withdrawal and metabolic stability. The terminal alcohol enables straightforward functionalization, facilitating coupling reactions in medicinal chemistry. Its bench-stable, moisture-tolerant nature simplifies handling in synthetic workflows.

Application

(2-(Trifluoromethyl)pyridin-4-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient incorporation of a polar trifluoromethyl-pyridyl motif. Its aldehyde functionality facilitates straightforward derivatization via nucleophilic addition, oximation, or reductive amination, while the pyridine ring supports metal-catalyzed coupling reactions. The compound exhibits excellent bench stability and compatibility with common protecting group strategies, making it well-suited for multi-step synthesis and API development workflows.

Synthesis

  • Route1

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
  • Route2

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.5927
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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