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2-Chloroimidazo[1,2-a]pyridine-3-carbonitrile

  • CAS No. 131773-48-3

  • Cat. No. CS-0597753
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Chloroimidazo[1,2-a]pyridine-3-carbonitrile|CS-0597753

Structure of 131773-48-3

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General Information

  • CAS No. 131773-48-3
  • Cat. No. CS-0597753
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄ClN₃
  • Molecular Weight 177.59
  • Synonym(s) None
  • SMILES N#CC1=C(Cl)N=C2C=CC=CN21

Description

2-Chloroimidazo[1,2-a]pyridine-3-carbonitrile is a heterocyclic building block featuring a chlorinated imidazopyridine core with a nitrile handle. This electron-deficient scaffold integrates readily into medicinal chemistry campaigns, offering high reactivity in cross-coupling and nucleophilic substitution reactions. The molecule's planar structure and polar functional groups enhance solubility in common organic solvents while maintaining bench stability under standard conditions.

Application

2-Chloroimidazo[1,2-a]pyridine-3-carbonitrile serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to imidazopyridine-based scaffolds. Its dual functionality—reactive chloro group and nitrile handle—facilitates palladium-catalyzed cross-coupling and nucleophilic substitution reactions. The compound exhibits excellent bench stability and compatibility with diverse functional groups, supporting scalable synthesis of bioactive molecules.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   41.09
  • LogP   1.85938
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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