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Structure of 131864-68-1
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This chiral pyridine ligand features two (R)-4-ethyl-4,5-dihydrooxazol-2-yl groups at the 2,6-positions, providing a rigid, electron-rich coordination environment. It delivers high enantioselectivity in palladium-catalyzed cross-coupling reactions and exhibits excellent stability under standard reaction conditions.
2,6-Bis((R)-4-ethyl-4,5-dihydrooxazol-2-yl)pyridine serves as a chiral, bidentate ligand in transition metal catalysis, enabling stereoselective cross-coupling reactions. Its oxazoline rings provide robust coordination to palladium and nickel centers, enhancing catalyst stability and enantioselectivity in C–C bond formation. The ethyl substituent improves solubility and reduces aggregation, while the pyridine backbone ensures strong metal binding. This ligand facilitates efficient coupling under mild conditions with broad functional group tolerance, making it suitable for scalable synthesis of complex chiral intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: