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CS-W001157 4
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2,3-O-(1-Methylethylidene)-D-ribose

  • CAS No. 13199-25-2

  • Cat. No. CS-0015228
  • Purity≥95%
  • MDL No.MFCD02094261

*For research and further manufacturing use only, not for direct human use.

2,3-O-(1-Methylethylidene)-D-ribose|CS-0015228

Structure of 13199-25-2

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General Information

  • CAS No. 13199-25-2
  • Cat. No. CS-0015228
  • Purity ≥95%
  • MDL No. MFCD02094261
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄O₅
  • Molecular Weight 190.19
  • Synonym(s) None
  • SMILES OC[C@H]([C@]1([H])[C@@H](OC(C)(O1)C)C=O)O

Description

Fmoc-6-aminohexanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Fmoc-6-aminohexanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Synthesis

  • Route1

    References

    • Behr, Jean-Bernard Tetrahedron Letters, 2009 , vol. 50, # 31 p. 4498 - 4501

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   75.99
  • LogP   -0.9414
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   3

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