Propargyl-C1-NHS ester

Name: Propargyl-C1-NHS ester
Brand: ChemScene
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CAS No. 132178-37-1
Cat. No. CS-0105047
Purity≥95%
MDL No.MFCD22577791

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 132178-37-1

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Description

Propargyl-C1-NHS ester enables site-specific bioconjugation via copper-free click chemistry. The reactive NHS ester facilitates efficient coupling to amine-containing biomolecules, while the terminal alkyne group supports orthogonal labeling with azide-functionalized probes. This bifunctional reagent offers high stability under standard conditions and delivers reliable conjugation in aqueous environments.

Application

Propargyl-C1-NHS ester serves as a versatile bioconjugation reagent, enabling efficient coupling to primary amines under mild aqueous conditions. The propargyl group provides a reliable handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC), facilitating site-specific labeling and conjugation in protein and oligonucleotide workflows. Its C1 spacer optimizes solubility and reduces steric hindrance, while the NHS ester offers high reactivity and stability during storage and handling.

General Information

CAS No. 132178-37-1
Cat. No. CS-0105047
Purity ≥95%
MDL No. MFCD22577791
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₉NO₄
Molecular Weight 195.17
Synonym(s) None
SMILES C#CCCC(ON1C(CCC1=O)=O)=O

Computational Chemistry Data

TPSA 63.68
LogP 0.007
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 3

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Life Science Linker Alkyne PEG

Life Science Linker Propargyl PEG

Life Science ADC Related Compound Non-cleavable linker

Life Science Click Chemistry Reagents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

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Propargyl-C1-NHS ester

CAS No. 132178-37-1

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