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Structure of 132993-23-8
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4-Fluorophenyltriflate serves as a highly reactive arylating agent in cross-coupling reactions, leveraging the electron-withdrawing fluorine substituent to enhance triflate leaving group efficiency. This bench-stable reagent enables selective C–C bond formation under mild conditions, offering predictable regiochemistry and compatibility with sensitive functional groups.
4-Fluorophenyltriflate serves as a versatile aryl triflate building block in transition-metal-catalyzed cross-coupling reactions. Its stability under ambient conditions and compatibility with palladium- and nickel-based catalysis enable efficient Suzuki, Stille, Negishi, and Buchwald–Hartwig couplings. The fluorine substituent enhances reactivity in electrophilic substitution and provides orthogonal functionalization potential, making it a practical choice for synthesizing biaryl scaffolds and functionalized heterocycles in medicinal chemistry and materials science.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3265
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: