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CS-W001157 4
Total: USD 88.00

5-Bromo-2-chloro-3-(difluoromethyl)pyridine

  • CAS No. 1332392-76-3

  • Cat. No. CS-0142305
  • Purity≥97%
  • MDL No.MFCD22199307
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-chloro-3-(difluoromethyl)pyridine|CS-0142305

Structure of 1332392-76-3

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Description

5-Bromo-2-chloro-3-(difluoromethyl)pyridine features a sterically constrained pyridine core bearing bromo, chloro, and difluoromethyl substituents at strategic positions. This electron-deficient heterocycle integrates readily into cross-coupling reactions, enabling efficient access to advanced pharmaceutical intermediates and functionalized materials under standard conditions.

Application

5-Bromo-2-chloro-3-(difluoromethyl)pyridine serves as a versatile building block for constructing bioactive heterocycles, enabling palladium-catalyzed cross-coupling reactions with high functional group tolerance. The difluoromethyl group enhances metabolic stability and modulates lipophilicity, while the bromo and chloro substituents facilitate sequential functionalization. Its bench-stable nature and compatibility with standard synthetic workflows make it ideal for medicinal chemistry and process development applications.

General Information

  • CAS No. 1332392-76-3
  • Cat. No. CS-0142305
  • Purity ≥97%
  • MDL No. MFCD22199307
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrClF₂N
  • Molecular Weight 242.45
  • Synonym(s) None
  • SMILES FC(C1=CC(Br)=CN=C1Cl)F

Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.4351
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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