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CS-W001157 4
Total: USD 88.00

Dolutegravir intermediate-1

  • CAS No. 1335210-23-5

  • Cat. No. CS-0018060
  • Molecule weight315.28
  • Purity≥98%
  • MDL No.MFCD28978322

*For research and further manufacturing use only, not for direct human use.

Dolutegravir intermediate-1|CS-0018060

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General Information

  • CAS No. 1335210-23-5
  • Cat. No. CS-0018060
  • Purity ≥98%
  • MDL No. MFCD28978322
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₇NO₈
  • Molecular Weight 315.28
  • Synonym(s) None
  • SMILES O=C(C1=C(OC)C(C(C(O)=O)=CN1CC(OC)OC)=O)OC

Description

Dolutegravir intermediate-1 is a key synthetic precursor featuring a pyrrolidinone core with strategically positioned nitrogen heterocycles. This bench-stable, moisture-tolerant compound integrates seamlessly into late-stage coupling reactions, enabling efficient access to dolutegravir through robust C–N bond formation under standard conditions.

Application

Dolutegravir intermediate-1 serves as a key building block in the synthesis of dolutegravir, a clinically approved HIV integrase inhibitor. It features a pyrrolotriazine core with strategically positioned functional groups enabling efficient coupling and cyclization steps. The compound exhibits excellent bench stability, facilitates straightforward purification, and demonstrates high compatibility with standard synthetic transformations used in antiviral API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   113.29
  • LogP   -0.0394
  • H_Acceptors   8
  • H_Donors   1
  • Rotatable_Bonds   7

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