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Structure of 1335210-23-5
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Dolutegravir intermediate-1 is a key synthetic precursor featuring a pyrrolidinone core with strategically positioned nitrogen heterocycles. This bench-stable, moisture-tolerant compound integrates seamlessly into late-stage coupling reactions, enabling efficient access to dolutegravir through robust C–N bond formation under standard conditions.
Dolutegravir intermediate-1 serves as a key building block in the synthesis of dolutegravir, a clinically approved HIV integrase inhibitor. It features a pyrrolotriazine core with strategically positioned functional groups enabling efficient coupling and cyclization steps. The compound exhibits excellent bench stability, facilitates straightforward purification, and demonstrates high compatibility with standard synthetic transformations used in antiviral API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: