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CS-W001157 4
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1-(3-Chloro-4-fluorophenyl)-1H-pyrrole-2,5-dione

  • CAS No. 134220-37-4

  • Cat. No. CS-0307635
  • Molecule weight225.60
  • Purity95+%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(3-Chloro-4-fluorophenyl)-1H-pyrrole-2,5-dione|CS-0307635

Structure of 134220-37-4

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General Information

  • CAS No. 134220-37-4
  • Cat. No. CS-0307635
  • Purity 95+%
  • MDL No. None
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₅ClFNO₂
  • Molecular Weight 225.60
  • Synonym(s) 1-(3-CHLORO-4-FLUORO-PHENYL)-PYRROLE-2,5-DIONE
  • SMILES C1=CC(=C(C=C1N2C(=O)C=CC2=O)Cl)F

Synthesis

  • Route1
    • null|null
      108-31-6
    • 4-Fluoro-3-chloroaniline Gefitinib Impurity|CS-0229026
      367-21-5
    • ~%
    • 1-(3-Chloro-4-fluorophenyl)-1H-pyrrole-2,5-dione|CS-0307635
      134220-37-4

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 9 p. 2876 - 2879
  • Route2
    • 4-((3-Chloro-4-fluorophenyl)amino)-4-oxobut-2-enoic acid|CS-0368950
      196804-60-1
    • ~%
    • 1-(3-Chloro-4-fluorophenyl)-1H-pyrrole-2,5-dione|CS-0307635
      134220-37-4

    References

    • Budke, Brian; Kalin, Jay H.; Pawlowski, Michal; Zelivianskaia, Anna S.; Wu, Megan; Kozikowski, Alan P.; Connell, Philip P. Journal of Medicinal Chemistry, 2013 , vol. 56, # 1 p. 254 - 263
  • Route3
    • 4-Fluoro-3-chloroaniline Gefitinib Impurity|CS-0229026
      367-21-5
    • ~%
    • 1-(3-Chloro-4-fluorophenyl)-1H-pyrrole-2,5-dione|CS-0307635
      134220-37-4

    References

    • Journal of Medicinal Chemistry, , vol. 56, # 1 p. 254 - 263

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331-H341
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.38
  • LogP   1.9085
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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