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Structure of 1343835-81-3
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1-(Tetrahydrofuran-3-yl)-1H-pyrazole-4-carboxylic acid combines a tetrahydrofuran-3-yl group with a pyrazole-4-carboxylic acid scaffold, delivering a polar, bench-stable heterocyclic building block. This structure integrates a rigid, electron-deficient pyrazole core with a flexible tetrahydrofuran moiety, enabling tailored solubility and conformational control in synthetic routes. The carboxylic acid functionality facilitates direct coupling or derivatization under standard conditions, supporting efficient access to bioactive analogs in medicinal chemistry campaigns.
1-(Tetrahydrofuran-3-yl)-1H-pyrazole-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. The pyrazole core exhibits robust functional group tolerance and facilitates coupling reactions with amines and alcohols under standard conditions. Its tetrahydrofuran substituent enhances solubility and modulates molecular polarity, supporting efficient purification and downstream derivatization. This compound functions effectively in peptide coupling, Suzuki-Miyaura cross-coupling, and amide bond formation workflows common in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H332
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: