1-(Tetrahydrofuran-3-yl)-1H-pyrazole-4-carboxylic acid

Name: 1-(Tetrahydrofuran-3-yl)-1H-pyrazole-4-carboxylic acid
Brand: ChemScene
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CAS No. 1343835-81-3
Cat. No. CS-0075015
Purity≥97%
MDL No.MFCD19611395

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-(Tetrahydrofuran-3-yl)-1H-pyrazole-4-carboxylic acid|CS-0075015

Structure of 1343835-81-3

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General Information

CAS No. 1343835-81-3
Cat. No. CS-0075015
Purity ≥97%
MDL No. MFCD19611395
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₁₀N₂O₃
Molecular Weight 182.18
Synonym(s) None
SMILES O=C(O)C1=CN(N=C1)C2CCOC2

Description

1-(Tetrahydrofuran-3-yl)-1H-pyrazole-4-carboxylic acid combines a tetrahydrofuran-3-yl group with a pyrazole-4-carboxylic acid scaffold, delivering a polar, bench-stable heterocyclic building block. This structure integrates a rigid, electron-deficient pyrazole core with a flexible tetrahydrofuran moiety, enabling tailored solubility and conformational control in synthetic routes. The carboxylic acid functionality facilitates direct coupling or derivatization under standard conditions, supporting efficient access to bioactive analogs in medicinal chemistry campaigns.

Application

1-(Tetrahydrofuran-3-yl)-1H-pyrazole-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds. The pyrazole core exhibits robust functional group tolerance and facilitates coupling reactions with amines and alcohols under standard conditions. Its tetrahydrofuran substituent enhances solubility and modulates molecular polarity, supporting efficient purification and downstream derivatization. This compound functions effectively in peptide coupling, Suzuki-Miyaura cross-coupling, and amide bond formation workflows common in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

TPSA 64.35
LogP 0.5427
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydrofuran compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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1-(Tetrahydrofuran-3-yl)-1H-pyrazole-4-carboxylic acid

CAS No. 1343835-81-3

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