(R)-1-Boc-2-piperidinemethanol

Name: (R)-1-Boc-2-piperidinemethanol
Brand: ChemScene
Availability: InStock
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CAS No. 134441-61-5
Cat. No. CS-W003219
Purity≥97%
MDL No.MFCD04973120

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-1-Boc-2-piperidinemethanol|CS-W003219

Structure of 134441-61-5

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Description

(R)-1-Boc-2-piperidinemethanol features a stereochemically defined piperidine core with a robust Boc-protected amine and hydroxymethyl group. This configuration enables direct incorporation into chiral scaffolds for medicinal chemistry, offering enhanced solubility and stability under standard conditions. The protected amine facilitates sequential functionalization without racemization.

Application

(R)-1-Boc-2-piperidinemethanol serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to piperidine-containing scaffolds. The Boc-protected amine and pendant hydroxyl group offer orthogonal functionalization potential, facilitating downstream modifications via standard coupling, reduction, or derivatization protocols. Its bench-stable solid form and compatibility with common reaction conditions make it well-suited for multi-step synthesis and scale-up applications.

General Information

CAS No. 134441-61-5
Cat. No. CS-W003219
Purity ≥97%
MDL No. MFCD04973120
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₁NO₃
Molecular Weight 215.29
Synonym(s) 1-Piperidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2R)-
SMILES OC[C@H]1CCCCN1C(=O)OC(C)(C)C

Computational Chemistry Data

TPSA 49.77
LogP 1.7683
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-1-Boc-2-piperidinemethanol

CAS No. 134441-61-5

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