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Methyl 5-fluoro-3-methylpicolinate

  • CAS No. 1346148-32-0

  • Cat. No. CS-0153174
  • Purity≥98%
  • MDL No.MFCD22560016

*For research and further manufacturing use only, not for direct human use.

Methyl 5-fluoro-3-methylpicolinate|CS-0153174

Structure of 1346148-32-0

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General Information

  • CAS No. 1346148-32-0
  • Cat. No. CS-0153174
  • Purity ≥98%
  • MDL No. MFCD22560016
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈FNO₂
  • Molecular Weight 169.15
  • Synonym(s) 2-Pyridinecarboxylic acid, 5-fluoro-3-methyl-, methyl ester
  • SMILES CC1=CC(=CN=C1C(=O)OC)F

Description

Methyl 5-fluoro-3-methylpicolinate is a fluorinated pyridine derivative featuring a methyl ester group at the picolinic acid core. This electron-deficient heterocycle integrates readily into synthetic routes requiring polar, stable intermediates. The para-fluoro and ortho-methyl substituents modulate reactivity and solubility, enabling efficient coupling in medicinal chemistry and materials synthesis under standard conditions.

Application

Methyl 5-fluoro-3-methylpicolinate serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its ortho-substituted pyridine core offers enhanced stability and predictable reactivity in cross-coupling and nucleophilic substitution reactions. The methyl ester facilitates downstream derivatization, while the 5-fluoro and 3-methyl groups provide orthogonal functional handles for sequential modifications. Functions reliably in standard synthetic workflows requiring bench-stable, high-purity intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.31572
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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