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CS-W001157 4
Total: USD 88.00

6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID

  • CAS No. 1346702-54-2

  • Cat. No. CS-W000481
  • Molecule weight283.12
  • Purity≥98%
  • MDL No.MFCD26407123

*For research and further manufacturing use only, not for direct human use.

6-BROMO-1-ISOPROPYL-1H-INDAZOLE-4-CARBOXYLIC ACID|CS-W000481

Structure of 1346702-54-2

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General Information

  • CAS No. 1346702-54-2
  • Cat. No. CS-W000481
  • Purity ≥98%
  • MDL No. MFCD26407123
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁BrN₂O₂
  • Molecular Weight 283.12
  • Synonym(s) 6-bromo-1-propan-2-ylindazole-4-carboxylic acid
  • SMILES CC(C)n1ncc2c(cc(Br)cc12)C(O)=O

Description

6-Bromo-1-isopropyl-1H-indazole-4-carboxylic acid integrates a brominated indazole core with a carboxylic acid handle, enabling direct coupling in cross-coupling and amide formation reactions. The isopropyl group enhances solubility and steric profile, while the electron-deficient bromine facilitates palladium-catalyzed transformations under standard conditions.

Application

6-Bromo-1-isopropyl-1H-indazole-4-carboxylic acid serves as a versatile building block for the synthesis of biologically active indazole derivatives. The bromo group enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid facilitates amide bond formation and derivatization. Its stability under standard reaction conditions and compatibility with diverse functional groups make it suitable for medicinal chemistry campaigns targeting kinase inhibitors and other pharmaceutical scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   3.0779
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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