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Structure of 1347750-82-6
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Thiol-PEG3-acid features a terminal thiol group conjugated to a three-ethylene glycol spacer terminating in a carboxylic acid. This bifunctional architecture enables site-specific bioconjugation via thiol-maleimide or thiol-ene reactions, while the acid moiety facilitates coupling to amine-containing biomolecules. The PEG3 spacer provides enhanced solubility and reduced non-specific binding, making this reagent ideal for protein labeling, probe synthesis, and drug delivery applications.
Thiol-PEG3-acid serves as a versatile bifunctional linker for conjugation chemistries, combining a reactive thiol group with a terminal carboxylic acid. The PEG3 spacer provides enhanced solubility and reduced aggregation, while the thiol enables site-specific coupling to maleimides or gold surfaces, and the acid facilitates amide bond formation with amines under standard activation conditions. This structure offers excellent bench stability, clean purification profiles, and broad compatibility in peptide, antibody-drug conjugate, and nanoparticle functionalization workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: