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CS-W001157 4
Total: USD 88.00

Thiol-PEG3-acid

  • CAS No. 1347750-82-6

  • Cat. No. CS-0114525
  • Purity≥95%
  • MDL No.MFCD25424073
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Thiol-PEG3-acid|CS-0114525

Structure of 1347750-82-6

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Description

Thiol-PEG3-acid features a terminal thiol group conjugated to a three-ethylene glycol spacer terminating in a carboxylic acid. This bifunctional architecture enables site-specific bioconjugation via thiol-maleimide or thiol-ene reactions, while the acid moiety facilitates coupling to amine-containing biomolecules. The PEG3 spacer provides enhanced solubility and reduced non-specific binding, making this reagent ideal for protein labeling, probe synthesis, and drug delivery applications.

Application

Thiol-PEG3-acid serves as a versatile bifunctional linker for conjugation chemistries, combining a reactive thiol group with a terminal carboxylic acid. The PEG3 spacer provides enhanced solubility and reduced aggregation, while the thiol enables site-specific coupling to maleimides or gold surfaces, and the acid facilitates amide bond formation with amines under standard activation conditions. This structure offers excellent bench stability, clean purification profiles, and broad compatibility in peptide, antibody-drug conjugate, and nanoparticle functionalization workflows.

General Information

  • CAS No. 1347750-82-6
  • Cat. No. CS-0114525
  • Purity ≥95%
  • MDL No. MFCD25424073
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₈O₅S
  • Molecular Weight 238.30
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCOCCS

Computational Chemistry Data

  • TPSA   64.99
  • LogP   0.4407
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   11

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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