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CS-W001157 4
Total: USD 88.00

2,2-Difluoroethyl 4-methylbenzenesulfonate

  • CAS No. 135206-84-7

  • Cat. No. CS-W018381
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,2-Difluoroethyl 4-methylbenzenesulfonate|CS-W018381

Structure of 135206-84-7

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Description

2,2-Difluoroethyl 4-methylbenzenesulfonate is a bench-stable sulfonate ester featuring a difluoromethyl-bearing ether linkage. This electrophilic reagent facilitates efficient C–O bond formation under mild conditions, enabling selective functionalization of nucleophiles. The para-methyl group enhances lipophilicity and stability, while the electron-withdrawing trifluoromethyl-like motif promotes reactivity in cross-coupling and substitution processes.

Application

2,2-Difluoroethyl 4-methylbenzenesulfonate serves as a versatile electrophilic fluorinating agent and alkylating reagent in synthetic organic chemistry. It facilitates the efficient introduction of the 2,2-difluoroethyl group into nucleophiles under mild conditions, exhibiting good bench stability and compatibility with various functional groups. Its sulfonate leaving group enables reliable reactivity in SN2 transformations, making it a practical tool for constructing fluorinated building blocks in medicinal chemistry and process development workflows.

General Information

  • CAS No. 135206-84-7
  • Cat. No. CS-W018381
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀F₂O₃S
  • Molecular Weight 236.24
  • Synonym(s) 2,2-Difluoroethyl p-toluenesulfonate
  • SMILES FC(F)COS(C1=CC=C(C)C=C1)(=O)=O

Computational Chemistry Data

  • TPSA   43.37
  • LogP   1.96542
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   4

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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