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Structure of 135206-84-7
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2,2-Difluoroethyl 4-methylbenzenesulfonate is a bench-stable sulfonate ester featuring a difluoromethyl-bearing ether linkage. This electrophilic reagent facilitates efficient C–O bond formation under mild conditions, enabling selective functionalization of nucleophiles. The para-methyl group enhances lipophilicity and stability, while the electron-withdrawing trifluoromethyl-like motif promotes reactivity in cross-coupling and substitution processes.
2,2-Difluoroethyl 4-methylbenzenesulfonate serves as a versatile electrophilic fluorinating agent and alkylating reagent in synthetic organic chemistry. It facilitates the efficient introduction of the 2,2-difluoroethyl group into nucleophiles under mild conditions, exhibiting good bench stability and compatibility with various functional groups. Its sulfonate leaving group enables reliable reactivity in SN2 transformations, making it a practical tool for constructing fluorinated building blocks in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: