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CS-W001157 4
Total: USD 88.00

5-Bromo-3-fluoro-1-methylpyridin-2(1H)-one

  • CAS No. 1352152-46-5

  • Cat. No. CS-0151188
  • Purity≥98%
  • MDL No.MFCD23135714
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-fluoro-1-methylpyridin-2(1H)-one|CS-0151188

Structure of 1352152-46-5

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Description

5-Bromo-3-fluoro-1-methylpyridin-2(1H)-one features a fluorinated, brominated pyridinone core with a methyl group at the 1-position, delivering enhanced electron-withdrawing character and metabolic stability. This scaffold integrates readily into pharmaceutical intermediates, enabling efficient coupling reactions under standard conditions.

Application

5-Bromo-3-fluoro-1-methylpyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling late-stage functionalization via palladium-catalyzed cross-coupling. The bromo group facilitates Suzuki, Stille, and Negishi reactions, while the fluorine atom enhances metabolic stability and modulates electronic properties. The 1-methylpyridin-2-one core provides a stable, polar scaffold with favorable solubility and orthogonal reactivity for further derivatization. This compound exhibits excellent bench stability and is compatible with standard purification methods.

General Information

  • CAS No. 1352152-46-5
  • Cat. No. CS-0151188
  • Purity ≥98%
  • MDL No. MFCD23135714
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFNO
  • Molecular Weight 206.01
  • Synonym(s) 5-bromo-3-fluoro-1-methylpyridin-2-one
  • SMILES CN1C=C(C=C(C1=O)F)Br

Computational Chemistry Data

  • TPSA   22
  • LogP   1.2869
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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