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Structure of 1352152-46-5
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5-Bromo-3-fluoro-1-methylpyridin-2(1H)-one features a fluorinated, brominated pyridinone core with a methyl group at the 1-position, delivering enhanced electron-withdrawing character and metabolic stability. This scaffold integrates readily into pharmaceutical intermediates, enabling efficient coupling reactions under standard conditions.
5-Bromo-3-fluoro-1-methylpyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling late-stage functionalization via palladium-catalyzed cross-coupling. The bromo group facilitates Suzuki, Stille, and Negishi reactions, while the fluorine atom enhances metabolic stability and modulates electronic properties. The 1-methylpyridin-2-one core provides a stable, polar scaffold with favorable solubility and orthogonal reactivity for further derivatization. This compound exhibits excellent bench stability and is compatible with standard purification methods.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: