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CS-W001157 4
Total: USD 88.00

5-Bromo-3-fluoro-1-methylpyridin-2(1H)-one

  • CAS No. 1352152-46-5

  • Cat. No. CS-0151188
  • Purity≥98%
  • MDL No.MFCD23135714

*For research and further manufacturing use only, not for direct human use.

5-Bromo-3-fluoro-1-methylpyridin-2(1H)-one|CS-0151188

Structure of 1352152-46-5

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General Information

  • CAS No. 1352152-46-5
  • Cat. No. CS-0151188
  • Purity ≥98%
  • MDL No. MFCD23135714
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrFNO
  • Molecular Weight 206.01
  • Synonym(s) 5-bromo-3-fluoro-1-methylpyridin-2-one
  • SMILES CN1C=C(C=C(C1=O)F)Br

Description

5-Bromo-3-fluoro-1-methylpyridin-2(1H)-one features a fluorinated, brominated pyridinone core with a methyl group at the 1-position, delivering enhanced electron-withdrawing character and metabolic stability. This scaffold integrates readily into pharmaceutical intermediates, enabling efficient coupling reactions under standard conditions.

Application

5-Bromo-3-fluoro-1-methylpyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling late-stage functionalization via palladium-catalyzed cross-coupling. The bromo group facilitates Suzuki, Stille, and Negishi reactions, while the fluorine atom enhances metabolic stability and modulates electronic properties. The 1-methylpyridin-2-one core provides a stable, polar scaffold with favorable solubility and orthogonal reactivity for further derivatization. This compound exhibits excellent bench stability and is compatible with standard purification methods.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   22
  • LogP   1.2869
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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