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Ald-Ph-amido-PEG4-C2-NHS ester

  • CAS No. 1353011-74-1

  • Cat. No. CS-0105059
  • Purity≥97%
  • MDL No.MFCD20926371

*For research and further manufacturing use only, not for direct human use.

Ald-Ph-amido-PEG4-C2-NHS ester|CS-0105059

Structure of 1353011-74-1

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General Information

  • CAS No. 1353011-74-1
  • Cat. No. CS-0105059
  • Purity ≥97%
  • MDL No. MFCD20926371
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₃₀N₂O₁₀
  • Molecular Weight 494.49
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCNC(C2=CC=C(C=O)C=C2)=O

Description

Ald-Ph-amido-PEG4-C2-NHS ester features a reactive NHS ester group paired with a PEG4 spacer and a terminal aldehyde for site-specific conjugation. This bifunctional reagent enables efficient coupling to amine-containing biomolecules under physiological conditions, followed by selective oxime ligation. The hydrophilic PEG chain minimizes non-specific binding, enhancing solubility and stability in aqueous environments.

Application

Ald-Ph-amido-PEG4-C2-NHS ester serves as a versatile bifunctional linker for protein conjugation and bioconjugate synthesis. The aldehyde group enables site-specific coupling via reductive amination, while the NHS ester facilitates efficient amine-reactive attachment. The PEG4 spacer provides enhanced solubility and reduced steric hindrance, and the phenylamido moiety offers improved hydrolytic stability compared to standard amides. This reagent functions reliably in aqueous buffers at physiological pH, enabling robust conjugation workflows with minimal aggregation.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   146.77
  • LogP   0.2926
  • H_Acceptors   10
  • H_Donors   1
  • Rotatable_Bonds   18

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