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Structure of 1354356-24-3
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tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate delivers a boronate-functionalized pyridine scaffold with enhanced stability and compatibility in Suzuki-Miyaura cross-coupling. The tetramethyl-dioxaborolane moiety enables efficient palladium-catalyzed transformations under mild conditions, while the tert-butyl ester facilitates straightforward deprotection to yield the corresponding carboxylic acid. This reagent streamlines access to complex heterocyclic architectures in medicinal chemistry and materials synthesis.
tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The picolinamide moiety provides a robust nitrogen-directed coupling site, while the tert-butyl ester offers bench stability and orthogonal deprotection. Compatible with diverse aryl and heteroaryl electrophiles, it facilitates efficient access to functionalized pyridine derivatives used in medicinal chemistry and materials science.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: