(R)-2,2'-Bis(di-p-tolylphosphino)-4,4',6,6'-tetramethoxy)-1,1'-biphenyl

Name: (R)-2,2'-Bis(di-p-tolylphosphino)-4,4',6,6'-tetramethoxy)-1,1'-biphenyl
Brand: ChemScene
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CAS No. 1365531-81-2
Cat. No. CS-0108700
Purity≥98%
MDL No.MFCD19443623

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(R)-2,2'-Bis(di-p-tolylphosphino)-4,4',6,6'-tetramethoxy)-1,1'-biphenyl|CS-0108700

Structure of 1365531-81-2

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Description

(R)-2,2'-Bis(di-p-tolylphosphino)-4,4',6,6'-tetramethoxy-1,1'-biphenyl is a sterically hindered, electron-rich phosphine ligand designed for palladium-catalyzed cross-coupling reactions. The tetramethoxy substitution enhances solubility and stability under reaction conditions, while the chiral biphenyl backbone provides precise control over stereochemistry in asymmetric transformations. This ligand integrates seamlessly into catalytic systems requiring robust performance and high selectivity.

Application

(R)-2,2'-Bis(di-p-tolylphosphino)-4,4',6,6'-tetramethoxy-1,1'-biphenyl serves as a highly functional, bench-stable ligand in palladium-catalyzed cross-coupling reactions. Its electron-rich phosphine centers enable efficient formation of C–C and C–heteroatom bonds under mild conditions. The tetramethoxy substitution enhances solubility and stability, while the steric bulk supports high selectivity in Suzuki-Miyaura and Negishi couplings. Ideal for complex molecule assembly in medicinal chemistry and materials synthesis.

General Information

CAS No. 1365531-81-2
Cat. No. CS-0108700
Purity ≥98%
MDL No. MFCD19443623
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄₄H₄₄O₄P₂
Molecular Weight 698.77
Synonym(s) (4,4',6,6'-Tetramethoxy-2,2'-biphenyldiyl)bis[bis(4-methylphenyl)phosphine]
SMILES CC(C=C1)=CC=C1P(C2=CC=C(C)C=C2)C3=C(C4=C(OC)C=C(OC)C=C4P(C5=CC=C(C)C=C5)C6=CC=C(C)C=C6)C(OC)=CC(OC)=C3

Computational Chemistry Data

TPSA 36.92
LogP 8.13808
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 11

Safety Information

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Signal Word : N/A	UN#: N/A
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Hazard Statements : N/A
Precautionary Statements : N/A

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(R)-2,2'-Bis(di-p-tolylphosphino)-4,4',6,6'-tetramethoxy)-1,1'-biphenyl

CAS No. 1365531-81-2

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