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Structure of 1373503-48-0
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2-(3,3-Difluorocyclobutyl)acetic acid features a rigid difluorocyclobutane ring that imparts enhanced metabolic stability and lipophilicity. The acetic acid moiety enables direct conjugation or derivatization in synthetic routes. This structure combines steric constraint with fluorine-directed electronic effects, making it valuable for medicinal chemistry applications requiring precise pharmacophore positioning.
2-(3,3-Difluorocyclobutyl)acetic acid serves as a versatile building block for fluorinated cyclobutane-containing scaffolds in medicinal chemistry. Its difluorocyclobutyl moiety imparts enhanced metabolic stability and modulates lipophilicity, while the carboxylic acid group enables direct coupling or derivatization in standard peptide and amide formation protocols. The compound exhibits good bench stability and facilitates efficient purification via crystallization or standard chromatography.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: