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Structure of 13736-79-3
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1-Methoxy-2-(methylsulfonyl)benzene features a methoxy group ortho to a strongly electron-withdrawing methylsulfonyl moiety, creating a polarized aromatic system ideal for directed functionalization. This electronic asymmetry enhances regioselectivity in cross-coupling reactions and improves solubility in polar organic solvents. The bench-stable compound integrates seamlessly into complex synthetic sequences requiring controlled reactivity and stable intermediates.
1-Methoxy-2-(methylsulfonyl)benzene serves as a versatile building block in medicinal chemistry and process development, enabling efficient access to substituted aromatic scaffolds. Its ortho-difunctionalized structure supports sequential transformations, with the methoxy group facilitating electrophilic substitution and the methylsulfonyl moiety providing enhanced solubility and metabolic stability. The compound exhibits excellent bench stability, mild reactivity under standard conditions, and compatibility with common coupling protocols, making it ideal for modular synthesis of pharmaceutical intermediates and functional materials.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: