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Structure of 1374659-32-1
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5-Chloro-2-(difluoromethyl)pyridine features a strategically positioned difluoromethyl group that enhances metabolic stability and modulates electronic properties. This electron-deficient pyridine scaffold supports efficient coupling reactions, enabling rapid access to bioactive heterocycles in medicinal chemistry. The molecule exhibits robust bench stability and compatibility with standard synthetic protocols.
5-Chloro-2-(difluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group at the pyridine 2-position. The chloro substituent facilitates subsequent cross-coupling reactions, while the difluoromethyl moiety imparts enhanced metabolic stability and modulated lipophilicity. This compound exhibits excellent bench stability and compatibility with standard reaction conditions, facilitating efficient synthesis of fluorinated heterocycles and API intermediates.
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H227-H301-H315-H319-H335
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Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501
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Lot numbers can be found on the outside label of a product: