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CS-W001157 4
Total: USD 88.00

(S)-Leucic acid

  • CAS No. 13748-90-8

  • Cat. No. CS-0000169
  • Purity≥98%
  • MDL No.MFCD00064214

*For research and further manufacturing use only, not for direct human use.

(S)-Leucic acid|CS-0000169

Structure of 13748-90-8

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General Information

  • CAS No. 13748-90-8
  • Cat. No. CS-0000169
  • Purity ≥98%
  • MDL No. MFCD00064214
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₂O₃
  • Molecular Weight 132.16
  • Synonym(s) (S)-2-Hydroxy-4-methylpentanoic acid
  • SMILES O=C(O)[C@@H](O)CC(C)C

Description

(S)-Leucic acid is a chiral α-amino acid derivative featuring a branched aliphatic side chain, offering high stereochemical purity for use in peptide synthesis and biochemical studies. This bench-stable, moisture-tolerant compound integrates readily into synthetic sequences requiring defined stereochemistry.

Application

(S)-Leucic acid serves as a chiral building block for the synthesis of bioactive peptides and pharmaceutical intermediates, offering high enantiomeric purity and stability under standard reaction conditions. Its well-defined stereochemistry enables reliable incorporation into complex molecular architectures, while its carboxylic acid functionality facilitates straightforward derivatization via esterification, amide coupling, or activation protocols. Functions reliably in solid-phase and solution-phase peptide synthesis workflows.

Synthesis

  • Route1
    • L-Leucine, 99%|CS-1269060
      61-90-5
    • ~86%
    • In-stock
      (S)-Leucic acid|CS-0000169
      13748-90-8

    References

    • Hu, Dennis X.; O'Brien, Matthew; Ley, Steven V. Organic Letters, 2012 , vol. 14, # 16 p. 4246 - 4249
  • Route2
    • null|null
      171598-10-0
    • ~%
    • In-stock
      (S)-Leucic acid|CS-0000169
      13748-90-8

    References

    • Helvetica Chimica Acta, , vol. 46, # 85 p. 766 - 780
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 114, # 27 p. 10704 - 10710

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   0.478
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   3

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