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CS-W001157 4
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6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline

  • CAS No. 1375301-92-0

  • Cat. No. CS-W007166
  • Molecule weight256.11
  • Purity≥98%
  • MDL No.MFCD11521590

*For research and further manufacturing use only, not for direct human use.

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline|CS-W007166

Structure of 1375301-92-0

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General Information

  • CAS No. 1375301-92-0
  • Cat. No. CS-W007166
  • Purity ≥98%
  • MDL No. MFCD11521590
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₇BN₂O₂
  • Molecular Weight 256.11
  • Synonym(s) None
  • SMILES CC1(C)C(C)(C)OB(C2=CC3=CN=CN=C3C=C2)O1

Description

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline integrates a boronate handle onto a quinazoline scaffold, enabling direct coupling in Suzuki-Miyaura reactions. The tetramethyl-dioxaborolane moiety ensures high stability and ease of handling under standard conditions. This compound serves as a key building block for bioactive heterocycles in medicinal chemistry.

Application

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)quinazoline serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl architectures. The tetramethylboronate moiety provides excellent bench stability, mild reaction conditions, and broad functional group tolerance, facilitating the synthesis of complex quinazoline-based scaffolds relevant to medicinal chemistry and materials science.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   44.24
  • LogP   1.929
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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