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((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol)

  • CAS No. 137536-94-8

  • Cat. No. CS-0035203
  • Molecule weight666.80
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol)|CS-0035203

Structure of 137536-94-8

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General Information

  • CAS No. 137536-94-8
  • Cat. No. CS-0035203
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₇H₃₈O₄
  • Molecular Weight 666.80
  • Synonym(s) (4R,5R)-(-)-2,2-Dimethyl-α,α,α',α'-tetra(1-naphthyl)-1,3-dioxolane-4,5-dimethanol
  • SMILES OC(C1=C(C=CC=C2)C2=CC=C1)(C3=CC=CC4=C3C=CC=C4)[C@H]5[C@H](C(C6=CC=CC7=C6C=CC=C7)(C8=C(C=CC=C9)C9=CC=C8)O)OC(C)(C)O5

Description

This chiral dioxolane diol features two naphthalen-1-ylmethyl groups positioned at the 4,5-aryl sites, delivering enhanced rigidity and steric shielding. The (4R,5R) stereochemistry ensures predictable conformational behavior in asymmetric synthesis. Designed for stability under standard conditions, it integrates seamlessly into complex molecular architectures requiring defined spatial orientation and resistance to racemization.

Application

((4R,5R)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol) serves as a stereochemically defined chiral synthon for the construction of complex polyfunctionalized heterocycles. Its rigid dioxolane framework provides excellent bench stability and facilitates orthogonal functional group manipulation. The di(naphthalen-1-yl)methanol moieties enable efficient coupling reactions and offer enhanced solubility in organic media, supporting scalable transformations in medicinal chemistry and natural product synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.92
  • LogP   9.9915
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   6

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