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Structure of 13764-20-0
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2-(Pyridin-2-yl)benzoic acid features a rigid, planar architecture with ortho-linked pyridine and benzoic acid moieties, enabling strong intermolecular coordination. This structural motif facilitates metal chelation and enhances solubility in polar solvents. The carboxylic acid group serves as a direct handle for amide coupling or esterification, streamlining conjugation in pharmaceutical intermediates and ligand design.
2-(Pyridin-2-yl)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds through standard coupling and cyclization protocols. Its ortho-linked pyridine and carboxylic acid functionalities offer enhanced solubility and directional reactivity, facilitating efficient derivatization via amide formation, esterification, or transition-metal-catalyzed cross-couplings. The molecule exhibits good bench stability and is readily purified by recrystallization, supporting its use in high-throughput synthesis and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: