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CS-W001157 4
Total: USD 88.00

6-(3-(Trifluoromethyl)phenoxy)picolinic acid

  • CAS No. 137640-84-7

  • Cat. No. CS-0515073
  • Purity≥98%
  • MDL No.MFCD00227526
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-(3-(Trifluoromethyl)phenoxy)picolinic acid|CS-0515073

Structure of 137640-84-7

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Description

6-(3-(Trifluoromethyl)phenoxy)picolinic acid features a trifluoromethyl-substituted phenoxy group linked to a picolinic acid scaffold, delivering enhanced electron-withdrawing character and improved metabolic stability. This structural motif enables efficient integration into bioactive scaffolds for medicinal chemistry applications.

Application

6-(3-(Trifluoromethyl)phenoxy)picolinic acid serves as a versatile building block for bioactive molecule synthesis, leveraging the electron-withdrawing trifluoromethyl group to modulate electronic properties and metabolic stability. The ortho-substituted phenoxy linkage enables predictable coupling reactions, while the picolinic acid scaffold facilitates amide formation and metal coordination—key features in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

General Information

  • CAS No. 137640-84-7
  • Cat. No. CS-0515073
  • Purity ≥98%
  • MDL No. MFCD00227526
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₈F₃NO₃
  • Molecular Weight 283.20
  • Synonym(s) Picolinafen acid metabolite
  • SMILES O=C(O)C1=NC(OC2=CC=CC(C(F)(F)F)=C2)=CC=C1

Computational Chemistry Data

  • TPSA   59.42
  • LogP   3.5909
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group :
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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