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CS-W001157 4
Total: USD 88.00

6-(3-(Trifluoromethyl)phenoxy)picolinic acid

  • CAS No. 137640-84-7

  • Cat. No. CS-0515073
  • Purity≥98%
  • MDL No.MFCD00227526

*For research and further manufacturing use only, not for direct human use.

6-(3-(Trifluoromethyl)phenoxy)picolinic acid|CS-0515073

Structure of 137640-84-7

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General Information

  • CAS No. 137640-84-7
  • Cat. No. CS-0515073
  • Purity ≥98%
  • MDL No. MFCD00227526
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₈F₃NO₃
  • Molecular Weight 283.20
  • Synonym(s) Picolinafen acid metabolite
  • SMILES O=C(O)C1=NC(OC2=CC=CC(C(F)(F)F)=C2)=CC=C1

Description

6-(3-(Trifluoromethyl)phenoxy)picolinic acid features a trifluoromethyl-substituted phenoxy group linked to a picolinic acid scaffold, delivering enhanced electron-withdrawing character and improved metabolic stability. This structural motif enables efficient integration into bioactive scaffolds for medicinal chemistry applications.

Application

6-(3-(Trifluoromethyl)phenoxy)picolinic acid serves as a versatile building block for bioactive molecule synthesis, leveraging the electron-withdrawing trifluoromethyl group to modulate electronic properties and metabolic stability. The ortho-substituted phenoxy linkage enables predictable coupling reactions, while the picolinic acid scaffold facilitates amide formation and metal coordination—key features in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Synthesis

  • Route1
    • Methyl 6-(3-(trifluoromethyl)phenoxy)picolinate|CS-0507999
      136227-55-9
    • ~%
    • In-stock
      6-(3-(Trifluoromethyl)phenoxy)picolinic acid|CS-0515073
      137640-84-7

    References

    • US5294597 A1, ;
  • Route2
    • 6-(3-(Trifluoromethyl)phenoxy)picolinonitrile|CS-1223510
      178108-95-7
    • ~%
    • In-stock
      6-(3-(Trifluoromethyl)phenoxy)picolinic acid|CS-0515073
      137640-84-7

    References

    • US6159901 A1, ;
  • Route3
    • null|null
      178108-83-3
    • null|null
      75-87-6
    • ~%
    • In-stock
      6-(3-(Trifluoromethyl)phenoxy)picolinic acid|CS-0515073
      137640-84-7

    References

    • US6159901 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   3.5909
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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