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7-Chloro-3-methyl-1H-indazole

  • CAS No. 1378582-62-7

  • Cat. No. CS-0499258
  • Molecule weight166.61
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Chloro-3-methyl-1H-indazole|CS-0499258

Structure of 1378582-62-7

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General Information

  • CAS No. 1378582-62-7
  • Cat. No. CS-0499258
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇ClN₂
  • Molecular Weight 166.61
  • Synonym(s) None
  • SMILES ClC1=CC=CC2=C1NN=C2C

Description

7-Chloro-3-methyl-1H-indazole is a heterocyclic compound featuring a chlorinated indazole core with a methyl group at the 3-position. This electron-deficient scaffold integrates readily into medicinal chemistry libraries, offering enhanced metabolic stability and favorable binding interactions in kinase inhibition studies.

Application

7-Chloro-3-methyl-1H-indazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its well-established reactivity profile supports palladium-catalyzed cross-coupling, nucleophilic substitution, and functionalization at the 7-chloro position, with the methyl group offering additional site for derivatization. The compound exhibits bench stability and compatibility with standard purification methods, facilitating integration into multi-step syntheses of pharmaceutical intermediates and targeted libraries.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.52472
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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