Lot numbers can be found on the outside label of a product:
tert-Butyl piperidine-4-carboxylate
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CAS No. 138007-24-6
- Cat. No. CS-W023023
- Purity≥97%
- MDL No.MFCD02684429
*For research and further manufacturing use only, not for direct human use.
Structure of 138007-24-6
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General Information
- CAS No. 138007-24-6
- Cat. No. CS-W023023
- Purity ≥97%
- MDL No. MFCD02684429
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₉NO₂
- Molecular Weight 185.26
- Synonym(s) tert-Butyl piperidine-4-carboxylatehydrochloride
- SMILES O=C(C1CCNCC1)OC(C)(C)C
Description
tert-Butyl piperidine-4-carboxylate features a protected piperidine scaffold ideal for medicinal chemistry applications. The tert-butyl ester group enables facile deprotection under mild acidic conditions, while the piperidine core provides a rigid, basic nitrogen site for molecular diversification. This compound serves as a key intermediate in the synthesis of bioactive molecules and drug candidates requiring controlled amine functionality.
Application
tert-Butyl piperidine-4-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds. Its tert-butyl ester group offers excellent stability and facilitates straightforward deprotection under mild acidic conditions. The molecule exhibits broad compatibility with standard coupling reactions and functions effectively in the synthesis of bioactive compounds, including kinase inhibitors and GPCR-targeted therapeutics.
Synthesis
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Route1
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882738-24-1 - ~74%
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In-stock
138007-24-6
References
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Istituto Di Ricerche Di Biologia Molecolare P. Angeletti SpA Patent: WO2006/38039 A1, 2006 ; Location in patent: Page/Page column 17; 29 ;
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Route2
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498-94-2 -
115-11-7 - ~%
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In-stock
138007-24-6
References
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US2010/317767 A1, ; Page/Page column 15 ;
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Route3
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480068-01-7 - ~71%
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In-stock
138007-24-6
References
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Gao, Jianxin; Wang, Poguang; Giese, Roger W. Analytical Chemistry, 2002 , vol. 74, # 24 p. 6397 - 6401
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 38.33
- LogP 1.3277
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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