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DBCO-NHS ester 2

  • CAS No. 1384870-47-6

  • Cat. No. CS-0087372
  • Molecule weight430.45
  • Purity≥95%
  • MDL No.MFCD22380763

*For research and further manufacturing use only, not for direct human use.

DBCO-NHS ester 2|CS-0087372

Structure of 1384870-47-6

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General Information

  • CAS No. 1384870-47-6
  • Cat. No. CS-0087372
  • Purity ≥95%
  • MDL No. MFCD22380763
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₂₂N₂O₅
  • Molecular Weight 430.45
  • Synonym(s) None
  • SMILES O=C1CCC(N1OC(CCCCC(N2C3=CC=CC=C3C#CC(C=CC=C4)=C4C2)=O)=O)=O

Description

DBCO-NHS ester 2 delivers efficient bioconjugation under physiological conditions, combining the strain-promoted cycloaddition of DBCO with the reactive NHS ester for rapid, site-specific labeling. This bench-stable reagent enables seamless coupling to primary amines on proteins and biomolecules, streamlining probe integration in chemical biology workflows.

Application

DBCO-NHS ester 2 is a bioorthogonal reagent that enables efficient, selective conjugation of primary amines under physiological conditions. It functions as a stable, water-tolerant coupling agent with high reactivity toward amine-containing biomolecules, facilitating site-specific labeling and probe immobilization. The cyclooctyne moiety enables rapid strain-promoted azide-alkyne cycloaddition (SPAAC), while the NHS ester provides reliable activation for amine functionalization. Ideal for protein modification, antibody-drug conjugate synthesis, and surface functionalization in complex biological matrices.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   83.99
  • LogP   3.1006
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   6

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