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CS-W001157 4
Total: USD 88.00

Sildenafil impurity 8

  • CAS No. 1391053-95-4

  • Cat. No. CS-0093840
  • Purity≥98%
  • MDL No.MFCD23704665

*For research and further manufacturing use only, not for direct human use.

Sildenafil impurity 8|CS-0093840

Structure of 1391053-95-4

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General Information

  • CAS No. 1391053-95-4
  • Cat. No. CS-0093840
  • Purity ≥98%
  • MDL No. MFCD23704665
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₃₂N₆O₄S
  • Molecular Weight 488.61
  • Synonym(s) None
  • SMILES O=C1N=C(NC=2C(=NN(C12)C)CC(C)C)C=3C=C(C=CC3OCC)S(=O)(=O)N4CCN(C)CC4

Description

A cell-permeable nucleoside compound that is processed intracellularly to form a phosphorylated metabolite, which activates adenosine monophosphate-activated protein kinase (AMPK) without disrupting the cellular concentrations of ATP, ADP, or AMP. Also acts as a regulator of de novo purine synthesis. Stimulates glucose uptake in both perfused and isolated muscle. AICAr-stimulated glucose transport is not affected by Wortmannin (Cat. No. 681675), a PI-3K inhibitor. Shown to inhibit the synthesis of triacylglycerol (TAG), diacylglycerol (DAG), and phospholipid, probably as a result of AMPK activation and the subsequent inhibition of sn-glycerol-3-phosphate acyltransferase (GPAT) by AMPK. Also reported to inhibit Hsp90 chaperone function. Imparts protection against cell death induced by glucose deprivation, chemical hypoxia, and exposure to glutamate and amyloid (A) peptide.

Safety Information

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GHS Pictogram :
GHS No : GHS07,GHS08
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H370-H372
Precautionary Statements : P260-P264-P270-P280-P302+P352-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   113.42
  • LogP   1.8569
  • H_Acceptors   8
  • H_Donors   1
  • Rotatable_Bonds   7

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