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Structure of 1393572-94-5
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1-(4-Chloro-3-fluoropyridin-2-yl)ethanone is a fluorinated pyridine ketone featuring a reactive acetyl group at the 2-position. This electron-deficient heterocycle integrates readily into cross-coupling reactions and serves as a key intermediate in medicinal chemistry. The chloro and fluoro substituents enhance metabolic stability and modulate electronic properties for targeted ligand design.
1-(4-Chloro-3-fluoropyridin-2-yl)ethanone serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated pyridine scaffolds prevalent in pharmaceutical intermediates. Its ketone functionality facilitates nucleophilic addition, enolization, and coupling reactions, while the ortho-halogen substituents support palladium-catalyzed cross-coupling processes. The compound exhibits good bench stability and compatibility with standard purification methods, making it suitable for scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: