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CS-W001157 4
Total: USD 88.00

2,4-dichloropyrimidin-5-ol

  • CAS No. 1395037-19-0

  • Cat. No. CS-W004351
  • Purity≥95%
  • MDL No.MFCD22570332
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,4-dichloropyrimidin-5-ol|CS-W004351

Structure of 1395037-19-0

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Description

2,4-Dichloropyrimidin-5-ol serves as a key heterocyclic building block in medicinal chemistry, featuring two chlorine substituents at electron-deficient positions that enhance reactivity in nucleophilic substitution. The hydroxyl group enables direct functionalization or hydrogen bonding in target interactions. This compound exhibits bench-stable handling and compatibility with diverse reaction conditions.

Application

2,4-Dichloropyrimidin-5-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution. The dichloro functionality allows selective displacement under mild conditions, facilitating the installation of diverse amine- and thiol-based side chains. Its bench-stable crystalline form simplifies handling and purification, while the hydroxyl group provides a handle for further derivatization. Widely employed in kinase inhibitor and antiviral agent synthesis, it functions as a key intermediate in standard coupling workflows.

General Information

  • CAS No. 1395037-19-0
  • Cat. No. CS-W004351
  • Purity ≥95%
  • MDL No. MFCD22570332
  • Storage -20°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂Cl₂N₂O
  • Molecular Weight 164.98
  • Synonym(s) 2,4-Dichloro-5-pyrimidinol
  • SMILES Clc1ncc(c(n1)Cl)O

Computational Chemistry Data

  • TPSA   46.01
  • LogP   1.489
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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